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To describe the persistence of effect following treatment with galcanezumab in adult patients with episodic or chronic migraine.

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Overall, the observed ADA titer in patients did not impact galcanezumab concentrations, CGRP concentrations, or the efficacy profile of galcanezumab.

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We prospectively collected demographic data and migraine characteristics from all the patients. Migraineurs have been identified to have chronically decreased serotonin levels which markedly increases during ictal periods.

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